Yeah, of current characters, Katic/Beckett is a great choice, and Cuoco/Penny belongs on the list. I'd add Emily Deschanel as Dr. Temperance "Bones" Brennan.
All time, though, isn't as hard for me. That's Allison Janney as Claudia Jean Cregg. I wrote yesterday that President Bartlett was the soul of The West Wing C.J. was its heart. A rich, fully developed character in every way.
I also want to mention S. Epatha Merkerson's fine work as Lt. Anita Van Buren, whose recently-completed 17 years is the longest run of any character on any Law and Order series. Which also, I believe, makes her the longest running African American character on any prime time series, and one of the longest running female characters. (The only ones I can think of who've been in more episodes are Marge Simpson, Lisa Simpson, Maggie Simpson, and Miss Kitty on Gunsmoke.)
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All time, though, isn't as hard for me. That's Allison Janney as Claudia Jean Cregg. I wrote yesterday that President Bartlett was the soul of The West Wing C.J. was its heart. A rich, fully developed character in every way.
I also want to mention S. Epatha Merkerson's fine work as Lt. Anita Van Buren, whose recently-completed 17 years is the longest run of any character on any Law and Order series. Which also, I believe, makes her the longest running African American character on any prime time series, and one of the longest running female characters. (The only ones I can think of who've been in more episodes are Marge Simpson, Lisa Simpson, Maggie Simpson, and Miss Kitty on Gunsmoke.)